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Conceptual Overview of Biological Age Estimation
Ahmed Salih1,2, Thomas Nichols3,4, Liliana Szabo1,2
1William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Aging and Disease
|May 16, 2023
Summary
Biological age, a more accurate aging measure than chronological age, can be estimated using biomarkers. The "age gap" metric offers insights into aging beyond chronological age alone, though its generalizability faces challenges.
Area of Science:
- Gerontology
- Biomarkers
- Aging research
Background:
- Chronological age is a limited indicator of biological aging.
- Aging is influenced by genetics and environmental factors.
- Biological age estimation uses biomarkers and mathematical models.
Purpose of the Study:
- To review biological age estimation and the "age gap" metric.
- To assess the utility of the "age gap" in understanding aging.
- To discuss challenges in biological age estimation, focusing on brain age.
Main Methods:
- Review of mathematical modeling for biological age estimation.
- Examination of the "age gap" as a metric.
- Discussion of model performance assessment.
Main Results:
- The "age gap" provides complementary aging information beyond chronological age.
- Associations between the "age gap" and exposures can be explored.
- Limited generalizability of effect sizes is a key challenge.
Conclusions:
- The "age gap" metric is a valuable tool for aging research.
- Standardization of methods is needed for broader applicability.
- Concepts are transferable across different biological age estimations.
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