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Related Experiment Video

Updated: Jul 30, 2025

Quantifying Social Motivation in Mice Using Operant Conditioning
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Measuring Motivation Using the Progressive Ratio Task in Adolescent Mice.

Emily Cambre1, Elena Christenfeld2, Arturo Herraez Torres3

  • 1Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, New York.

Current Protocols
|May 16, 2023
PubMed
Summary

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This study presents new protocols for studying reward seeking in adolescent mice. It details methods for weight management and behavioral training for the progressive ratio task, enabling developmental studies of motivation.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Animal Models

Background:

  • Alterations in reward seeking are central to psychiatric disorders like substance abuse and depression.
  • Studying motivation across the lifespan is crucial, given the neurodevelopmental component of many reward-related disorders.

Purpose of the Study:

  • To develop and validate protocols for assessing 'wanting' and motivation in adolescent mice using the progressive ratio task.
  • To address challenges in adapting the progressive ratio task for developing mice, including food restriction and behavioral shaping.

Main Methods:

  • Established a food restriction and weight management protocol suitable for growing adolescent mice.
  • Developed a protocol for operant conditioning, progressive ratio testing, and data analysis in adolescent mice.
Keywords:
adolescencefood restrictionmicemotivationprogressive ratio

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  • Compared lever presses versus nose pokes as operant responses in adolescent mice.

    • Main Results:

    • Successfully adapted the progressive ratio task for adolescent mice, allowing for developmental studies of motivation.
    • Provided optimized methods for weight management and behavioral shaping in young mice.
    • Assessed the efficacy of different operant responses (lever press vs. nose poke) for adolescent mice.

    Conclusions:

    • The developed protocols enable reliable assessment of motivational changes in adolescent mice.
    • This work facilitates research into the neurodevelopmental aspects of psychiatric disorders affecting reward seeking.
    • The study provides a foundation for future lifespan studies of motivation in mouse models.