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Updated: Jul 30, 2025

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Published on: August 5, 2016

Brucellosis-associated hepatitis.

Yusuf Arslan¹, Ali İrfan Baran², Mehmet Çelik³

¹Department of Infectious Diseases and Clinical Microbiology, Batman Training and Research Hospital, Batman, Turkey. dryusufarsln@gmail.com.

Irish Journal of Medical Science

|May 16, 2023

Summary

This summary is machine-generated.

Brucellosis can cause rare cases of hepatitis, but appropriate treatment leads to high rates of clinical and laboratory improvement. Chronic liver disease did not develop in any patients, indicating a good prognosis with timely intervention.

Keywords:

Brucellosis Cholestasis Hepatitis Liver involvement

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Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

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Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

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Published on: May 23, 2021

Area of Science:

Infectious Diseases
Hepatology
Microbiology

Background:

Brucellosis is a zoonotic disease with potential for multi-organ involvement.
While mild aminotransferase elevation is common, clinical hepatitis is a rare manifestation of brucellosis.
This study focuses on hospitalized patients with confirmed brucellosis hepatitis.

Purpose of the Study:

To describe the clinical characteristics and outcomes of hospitalized brucellosis hepatitis cases.
To evaluate the effectiveness of treatment in patients with brucellosis-induced liver involvement.
To identify factors influencing recovery time in brucellosis hepatitis.

Main Methods:

Retrospective analysis of 103 patients with significant hepatobiliary brucellosis over 13 years.
Hepatitis diagnosis based on elevated aminotransferases (≥5x ULN), elevated bilirubin (≥2 mg/dL), and/or hepatic lesions.
Microbiological analysis confirmed brucellosis diagnosis.

Main Results:

Hepatitis presentations included clinical (35.9%), cholestatic (17.5%), and mixed (46.6%).
Fever was the most common symptom (85.4%); aminoglycoside-based regimens were preferred treatments.
Mean normalization time for ALT, AST, and bilirubin was 15.2 days; no chronic liver disease developed.

Conclusions:

Brucellosis hepatitis shows a high clinical and laboratory response to appropriate treatment.
Blood culture positivity, secondary organ involvement, and AST/ALT ratio >1 were associated with delayed laboratory improvement.
Brucellosis hepatitis has a favorable prognosis with effective management, avoiding chronic liver disease development.