Related Experiment Video

Updated: Jul 30, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Cancer Cell-Extrinsic Roles for the Androgen Receptor in Prostate Cancer

Andrew W Hahn1, Bilal A Siddiqui1, Javier Leo2,3

  • 1Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Endocrinology
|May 16, 2023
PubMed

Insights

The androgen receptor (AR) plays a key role in prostate cancer, with new research revealing its function beyond cancer cells. Understanding these broader AR roles is crucial for improving prostate cancer treatment and patient outcomes.

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • The androgen receptor (AR) is a critical target in prostate cancer therapy for over 50 years.
  • Emerging evidence suggests AR expression and function extend to non-cancerous cells within the tumor microenvironment and systemically.
  • Established side effects of AR-targeted therapies, like bone complications and cardiometabolic disease, hint at broader physiological roles for AR.

Conclusions:

  • The androgen receptor (AR) exerts critical functions both within prostate cancer cells and in other cell types.
  • Understanding AR's broader roles in the tumor microenvironment and systemically is essential for developing more effective and safer prostate cancer treatments.
  • Future research should explore these non-canonical AR functions to improve therapeutic strategies and patient management.
Keywords:
adiposeandrogen receptorbonecardiovascularmetabolic syndromemuscleprostate cancertumor microenvironment

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