Related Experiment Video
Updated: Jul 30, 2025

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
Published on: February 2, 2024
Advancements in Systemic Therapy for Pancreatic Cancer
Timothy J Brown1,2, Kim A Reiss1,2, Mark H O'Hara1,2
1Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.
Abstract:
Outcomes for patients with advanced pancreatic cancer have improved in the past 12 years, mainly because of progress made in systemic therapies. New treatment strategies for advanced pancreatic cancer include switch maintenance with cytotoxic therapies, induction maintenance, and the utilization of targeted agents for patients with actionable variants, as well as ongoing development of cytotoxic regimens, such as NALIRIFOX. The activity of immunotherapy has been disappointing to date, but novel combinations and identifying appropriate patient populations may further unlock its potential.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
Chronic Pancreatitis II: Collaborative Care
Assessment:
Treatment Resistant Cancers
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy

