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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Pediatric Contact Dermatitis: A 10-Year Multicenter Retrospective Study.

Dan Slodownik1,2, Jonathan Bar1,2, Michal Solomon3

  • 1From the Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Dermatitis : Contact, Atopic, Occupational, Drug
|May 16, 2023
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Summary

Allergic contact dermatitis (ACD) in Israeli children is more common in females without atopic dermatitis. Acrylates are an emerging allergen, while methylisothiazolinone sensitivity is less frequent in those with atopic dermatitis.

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Area of Science:

  • Dermatology
  • Pediatric Allergy
  • Contact Dermatitis Research

Background:

  • Allergic contact dermatitis (ACD) is prevalent in children, but data on Israeli pediatric populations is limited.
  • Multicenter studies are needed to understand trends in pediatric contact sensitization in Israel.

Purpose of the Study:

  • To describe and analyze patch test results and trends in Israeli children (0-18 years) across four tertiary care centers from 2012-2022.
  • To identify demographic and atopic features associated with ACD and specific allergen sensitization.
  • To investigate emerging allergens and trends in pediatric ACD within the Israeli population.

Main Methods:

  • Retrospective analysis of 357 patch tests performed on children aged 0-18 years.
  • Utilized the European baseline series and additional clinically indicated series.
  • Assessed demographic data, atopic status, and patch test results, including allergen identification.

Main Results:

  • Females constituted 69% of the study population, with higher sensitization rates (P<0.05).
  • Patients without atopic dermatitis showed higher ACD diagnosis and patch test reactivity (P<0.05).
  • Common allergens included preservatives and metals; acrylates emerged as a significant sensitizer, alongside potential emerging allergens like linalool hyperoxide. Fragrance mix 2 and Mroxylon pereirae were rare. Methylisothiazolinone sensitivity was less common in patients with atopic dermatitis (P<0.05).

Conclusions:

  • ACD in Israeli children predominantly affects females without atopic dermatitis.
  • Acrylates should be considered for inclusion in baseline patch test series due to increasing prevalence.
  • Atopic dermatitis may confer a degree of protection against methylisothiazolinone sensitization.