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Maresin1: A multifunctional regulator in inflammatory bone diseases.

Zhanwei Zhang1, Chonghao Ji1, Daobin Wang2

  • 1Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China; Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China; Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China.

International Immunopharmacology
|May 16, 2023
PubMed
Summary

Maresin1 (MaR1), a specialized pro-resolving mediator, shows potential in treating inflammatory bone diseases by promoting bone homeostasis and regulating immune responses. MaR1 offers a promising therapeutic avenue for skeletal health.

Keywords:
BoneInflammationMaresin1Omega-3 fatty acidSpecialized pro-resolving mediators

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Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Immunology

Background:

  • Inflammation is essential for healing but chronic inflammation causes bone loss by disrupting osteogenic-osteoclastic balance.
  • Specialized pro-resolving mediators (SPMs), like Maresin1 (MaR1), are endogenous compounds that resolve inflammation.
  • MaR1, synthesized from omega-3 fatty acids by macrophages, exhibits potent anti-inflammatory and tissue-healing properties.

Purpose of the Study:

  • To review the multifaceted roles of Maresin1 (MaR1) in regulating inflammatory bone diseases.
  • To explore MaR1's potential as a therapeutic agent for skeletal homeostasis and inflammatory bone conditions.

Main Methods:

  • Literature review of studies investigating Maresin1 (MaR1) and its mechanisms.
  • Analysis of MaR1's effects on osteoblasts, macrophages, T cells, and antioxidant pathways.
  • Examination of MaR1's involvement in tissue regeneration and repair.

Main Results:

  • MaR1 stimulates osteoblast proliferation via LGR6 and promotes M2 macrophage polarization for immune control.
  • MaR1 exhibits anti-inflammatory effects by regulating T cells, inhibiting neutrophil infiltration, and activating NRF2 antioxidant signaling.
  • MaR1 supports periodontal ligament stem cell autophagy, enhances macrophage activity against bacteria, and promotes tissue repair.

Conclusions:

  • Maresin1 (MaR1) plays a critical role in resolving inflammation and maintaining bone homeostasis.
  • MaR1 demonstrates significant therapeutic potential for managing inflammatory bone diseases and skeletal metabolism disorders.