WEB shape modifications: angiography-histopathology correlations in rabbits.

Area of Science:

• Vascular Surgery
• Biomedical Engineering
• Radiology

Background:

• WEB Shape Modification (WSM) is a common occurrence following aneurysm treatment.
• Understanding the relationship between WSM and histopathological changes is crucial for evaluating treatment efficacy.

Purpose of the Study:

• To investigate the correlation between histopathological changes and the angiographic evolution of WEB devices over time.
• To assess the impact of WSM on aneurysm healing and occlusion status.

Main Methods:

• Utilized flat-panel computed tomography (FPCT) for quantitative WSM assessment.
• Calculated height ratio (HR) and width ratio (WR) at various time points up to 6 months post-implantation.
• Correlated WSM measurements with histopathological findings of aneurysm healing.

Main Results:

• Significant WSM was observed in a majority of WEB devices, with variations in both height and width.
• No significant correlation was found between WSM (HR or WR) and complete or incomplete aneurysm occlusion.
• Histopathological analysis showed a significant association between width variations (WR) and aneurysm healing/fibrosis at 1 month.

Conclusions:

• Longitudinal FPCT assessment confirms WSM affects both height and width of WEB devices.
• WSM did not show a significant association with aneurysm occlusion status.
• Width variations of WEB devices are significantly associated with aneurysm healing and fibrosis in the initial post-treatment month.