Ultrasound-responsive matters for biomedical applications

Area of Science:

• Biomedical Engineering
• Materials Science
• Acoustics

Background:

• Ultrasound (US) is a biofavorable mechanical wave with significant biomedical applications.
• US effects like cavitation, sonoluminescence, and sonoporation enable interactions with various materials.
• A growing range of matters exhibit responsiveness to US stimuli.

Purpose of the Study:

• To review current developments in US-responsive matters.
• To discuss the interactions between US and advanced materials.
• To explore potential biomedical applications and clinical translations.

Main Methods:

• Literature review of US-responsive materials.
• Analysis of US-induced biophysical and chemical effects.
• Discussion of US-facilitated biosensing, imaging, and therapeutics.

Main Results:

• US-responsive materials include breakable conjugations, sonosensitizers, fluorocarbons, microbubbles, and micro/nanorobots.
• Interactions yield biochemical products and enhanced mechanical effects.
• Potential applications span diagnostics, imaging, and therapeutics.

Conclusions:

• US-responsive matters offer diverse biomedical applications.
• Further research is needed for clinical translation.
• Challenges and future perspectives in US-responsive materials are outlined.