Changes in granule cells of the ferret olfactory bulb associated with imprinting on prey odours

The maturation of the granule cells of the ferret olfactory bulb around the time of odour imprinting has been examined. Rapid Golgi impregnation studies revealed a temporal overshoot in the development of the spines on the external and internal dendrites of the granule cells. In contrast, the number of somatic spines decreased continuously. Electron microscopical examinations of the synaptic contacts in the external plexiform layer revealed that the time course of synapse and reciprocal synapse formation was similar to that of the formation of the spines on the external dendrites. The results were taken as evidence that both the Golgi and the electron microscopical investigations described the same developmental process of postnatal synaptic rearrangement.