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Updated: Jul 30, 2025
A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
Published on: September 16, 2022
Antifungal therapy of Candida biofilms: Past, present and future
Olabayo H Ajetunmobi1, Hamid Badali1, Jesus A Romo1
1Department of Molecular Microbiology & Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, USA.
Abstract:
Virtually all Candida species linked to clinical candidiasis are capable of forming highly resistant biofilms on different types of surfaces, which poses an additional significant threat and further complicates therapy of these infections. There is a scarcity of antifungal agents, and their effectiveness, particularly against biofilms, is limited. Here we provide a historical perspective on antifungal agents and therapy of Candida biofilms. As we reflect upon the past, consider the present, and look towards the future of antifungal therapy of Candida biofilms, we believe that there are reasons to remain optimistic, and that the major challenges of Candida biofilm therapy can be conquered within a reasonable timeframe.
Insights
Candida biofilms are a major threat in clinical candidiasis due to their resistance. This review explores past, present, and future antifungal therapies for Candida biofilms, offering an optimistic outlook.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Antifungal Drug Development
Background:
- Candida species form highly resistant biofilms, complicating candidiasis treatment.
- Limited availability and efficacy of current antifungal agents against biofilms.
Purpose of the Study:
- To provide a historical perspective on antifungal agents and therapy for Candida biofilms.
- To analyze the current landscape and future directions in combating Candida biofilms.
Main Methods:
- Literature review of historical and current antifungal strategies.
- Analysis of challenges and advancements in Candida biofilm therapy.
Main Results:
- Candida biofilms present significant therapeutic challenges due to inherent resistance.
- Current antifungal agents show limited effectiveness against established biofilms.
Conclusions:
- Despite challenges, there are grounds for optimism in developing effective Candida biofilm therapies.
- Future research holds promise for overcoming major obstacles in Candida biofilm treatment.
