Mass: The Conundrum in Spine
P D Rath1, Sunil Katoch2, Abhijeet Kumar Agrawal1
1Department of Rheumatology, Max Healthcare, Saket, New Delhi, India.
Journal of Orthopaedic Case Reports
|May 16, 2023
Summary
Immunoglobulin (IgG4)-related disease is a rare condition that can affect the central nervous system, particularly the spinal cord. Diagnosis relies on histopathology, crucial for managing this rare IgG4-related spinal cord disease.
Area of Science:
- Rheumatology
- Neurology
- Pathology
Background:
- Immunoglobulin (IgG4)-related disease is a rare systemic condition affecting multiple organs.
- Central nervous system involvement is uncommon, with spinal cord presentation being exceptionally rare.
Observation:
- Two cases of IgG4-related disease involving the spinal cord are presented.
- Case 1: A 50-year-old male with spinal cord compression due to a dural mass positive for IgG4.
- Case 2: A 65-year-old female with paravertebral soft-tissue thickening compatible with IgG4 disease.
Findings:
- Histopathological examination is critical for diagnosing IgG4-related disease.
- The presented cases highlight the rarity of spinal cord involvement in IgG4-related disease.
- Diagnosis of IgG4-related spinal cord disease requires careful histopathological analysis.
Implications:
- Accurate diagnosis through histopathology is essential for effective management and prognosis of IgG4-related disease.
- Spinal cord manifestations of IgG4-related disease require prompt recognition and treatment to prevent recurrence.
- This study underscores the importance of considering IgG4-related disease in the differential diagnosis of spinal cord lesions.
Related Concept Videos
01:23Spinal Nerves: Anatomy
3.4K
Spinal nerves are pivotal conduits in the nervous system, bridging the central nervous system (CNS) with the peripheral nervous system (PNS). These nerves enable a complex communication network between the brain, spinal cord, and the rest of the body, facilitating sensory input, motor output, and autonomic functions.
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
3.4K
01:16Spinal Cord: Cross-sectional Anatomy
2.1K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
2.1K
01:16Vertebral Column: Regions and Curvature
3.8K
The vertebral column or spine is a flexible column that supports the head, neck, and body and allows for their movements. It also protects the spinal cord.
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
3.8K
01:15Spinal Cord: Gross Anatomy
3.4K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
3.4K
01:22Spinal Nerves: Plexus I
1.1K
Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
1.1K
01:21Spinal Nerves: Plexus II
727
The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
727