Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wildfire ash impacts the early development of the sea urchin Paracentrotus lividus.

Marine environmental research·2026
Same author

Controlling nanoparticle targeting: from physicochemical design to molecular recognition.

Nanomedicine (London, England)·2026
Same author

PEG-lipid structure controls in vitro PEG shedding, surface remodeling, and timing of lipid nanoparticle-mediated silencing.

Journal of colloid and interface science·2026
Same author

Programming Degradation and Drug Release Through Micropatterning of PLGA Films.

ACS applied materials & interfaces·2026
Same author

Anticancer LNA Oligonucleotides Detection through a Simple Paper-Based Platform.

ACS measurement science au·2026
Same author

Comparison and validation of a high-throughput lipid nanoparticle production and characterization workflow.

International journal of pharmaceutics·2026
Same journal

A Microenvironment-Driven Peptide Nanoplatform Enhances Ferroptosis and Antiangiogenic Activity for Triple-Negative Breast Cancer Therapy.

ACS biomaterials science & engineering·2026
Same journal

A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.

ACS biomaterials science & engineering·2026
Same journal

Biomimetic 3D-Printed Resorbable Extracellular Matrix-Guided Bone Regeneration Membrane Based on a Gelatin Methacrylate/Alginate-Hydroxyapatite Composite for Maxillofacial Surgery.

ACS biomaterials science & engineering·2026
Same journal

Sequential Biofunctionalization of a Choline-Based Monomeric Ionic Liquid and Polymerized Ionic Liquid: A Route to Dual Anionic Drug Polymer Conjugates of Piperacillin-Tazobactam.

ACS biomaterials science & engineering·2026
Same journal

Retinoic Acid-Functionalized Chitosan Polycationic Conjugates for Integrated Melanoma Therapy and Antibacterial Infection Control.

ACS biomaterials science & engineering·2026
Same journal

Nanotheranostics for Alzheimer's Disease: The Rising Promise of Fluorescent Carbon Dots.

ACS biomaterials science & engineering·2026
See all related articles

Related Experiment Video

Updated: Jul 30, 2025

A Microfluidic Technique to Probe Cell Deformability
09:47

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

11.4K

Assessing Differential Particle Deformability under Microfluidic Flow Conditions.

Marco E Miali1, Wei Chien1,2, Thomas Lee Moore1

  • 1Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.

ACS Biomaterials Science & Engineering
|May 17, 2023
PubMed
Summary
This summary is machine-generated.

A novel microfluidic chip effectively differentiates soft and rigid discoidal polymeric nanoconstructs (DPNs) based on their deformability under flow. This platform aids in assessing particle mechanical behavior for advanced drug delivery applications.

Keywords:
KOH wet etchingimage processingmicrofluidicsmodelingparticle dynamics

More Related Videos

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions
11:38

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

Published on: April 19, 2018

8.0K
Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli
10:35

Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli

Published on: August 13, 2016

9.0K

Related Experiment Videos

Last Updated: Jul 30, 2025

A Microfluidic Technique to Probe Cell Deformability
09:47

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

11.4K
Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions
11:38

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

Published on: April 19, 2018

8.0K
Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli
10:35

Designing Microfluidic Devices for Studying Cellular Responses Under Single or Coexisting Chemical/Electrical/Shear Stress Stimuli

Published on: August 13, 2016

9.0K

Area of Science:

  • Biomaterials Science
  • Microfluidics
  • Nanotechnology

Background:

  • Assessing the mechanical properties of complex-shaped nano- and micron-scale particles is crucial for drug delivery applications.
  • Existing methods for quantifying particle stiffness often lack accuracy under dynamic flow conditions.

Purpose of the Study:

  • To develop and validate a microfluidic chip platform for assessing the dynamic mechanical behavior of fluid-borne particles.
  • To differentiate between soft and rigid discoidal polymeric nanoconstructs (DPNs) based on their deformability.

Main Methods:

  • Fabrication of a microfluidic chip using potassium hydroxide (KOH) wet etching, featuring micropillars with decreasing openings (5 μm down to 1 μm).
  • Synthesis of discoidal polymeric nanoconstructs (DPNs) with varying poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) ratios to create soft and rigid particles.
  • Experimental testing of DPNs within the microfluidic chip under flow conditions.
  • Computational modeling using smoothed particle hydrodynamics (SPH) to simulate DPN behavior.

Main Results:

  • Rigid DPNs were predominantly trapped in the initial micropillar filtering modules.
  • Soft DPNs successfully navigated through multiple filtering modules, reaching the smallest openings (1 μm).
  • Computational simulations supported the experimental observations of particle behavior under flow.

Conclusions:

  • The developed microfluidic chip serves as an effective platform for evaluating the mechanical properties and deformability of complex particles in dynamic flow.
  • This combined experimental-computational approach enables quantitative analysis of particle behavior, advancing the design of particles for drug delivery.