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Modifications of miRNAs in intervertebral disc degeneration: a key to the future development of genetic-based
Fariborz Ghaffarpasand1, Sirous Sarhadi2, Mohammad Hesam Alavi3
1Research Center for Neuromodulation & Pain, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:
Intervertebral disc degeneration (IDD) is the main cause of low back pain, which is a healthcare concern associated with high social and economic burden. The current medical and surgical therapies are inadequate and ineffective. Several miRNAs have been identified that modulate (via up- or down-regulation) the pathogenesis of IDD through various signaling pathways. Understanding the nature of this regulation and their signaling pathways will enable researchers to manipulate miRNA regulation to develop miRNA-based therapies. The development of miRNA-based therapies opens a future window through which to decrease the IDD process or regenerate the intervertebral disc. In the near future, the obstacles associated with miRNA-based therapies will be overcome and these therapies will move from the bench to the bedside.
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