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Related Concept Videos

Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Canonical Wnt Signaling Pathway02:54

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Determination

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Teeth01:15

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Related Experiment Video

Updated: Jul 30, 2025

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
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Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development.

Yuhan Song1,2, Fujie Song3, Xuan Xiao1,2

  • 1Department of oral mucosa, Shanghai Stomatological Hospital, Fudan University, Shanghai, P. R. China.

Organogenesis
|May 17, 2023
PubMed
Summary
This summary is machine-generated.

Wnt signaling molecules are crucial for tooth development. This study reveals their stage-specific expression patterns in rat molars, offering insights into dental anomalies like supernumerary teeth and tooth agenesis.

Keywords:
Early tooth developmentRNA-seqWnt signaling pathwayexpression patternstooth agenesis

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • The Wnt signaling pathway is vital for embryonic tooth development.
  • Mutations in Wnt antagonists are linked to supernumerary teeth.
  • Stage-specific expression of Wnt molecules in early tooth development is largely unknown.

Purpose of the Study:

  • To determine the expression patterns of Wnt signaling molecules during rat first molar development.
  • To elucidate the role of Wnt signaling in different tooth development stages.
  • To investigate the link between Wnt signaling variations and tooth agenesis.

Main Methods:

  • RNA-sequencing (RNA-seq) analysis of rat first molar tooth germs at five distinct developmental stages.
  • Comprehensive literature review on Wnt signaling in tooth development.

Main Results:

  • Identified stage-specific expression profiles for numerous Wnt signaling molecules.
  • Detailed the functional roles of Wnt signaling molecules throughout tooth morphogenesis.
  • Established correlations between Wnt pathway dysregulation and conditions like tooth agenesis.

Conclusions:

  • Wnt signaling molecules exhibit dynamic, stage-specific expression during early tooth development.
  • Understanding these patterns is key to comprehending dental anomalies.
  • This research provides a foundation for further investigation into Wnt signaling's role in dental development and disease.