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Neuroprotection of fullerene in improving cognitive-behavioral disruptions and neurobiochemical enzymes activities
Davoud Malekzadeh1, Asadollah Asadi2, Arash Abdolmaleki3
1Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, 5166616471, Iran.
Abstract:
Aim: Here, we report the synthesis and evaluation of fullerene C60 nanoparticles' (FC60 NPs) therapeutic efficacy in animals with aluminum-induced oxidative stress. Materials & methods: Effects of FC60 NPs on the altered activity levels of neurobiochemical enzymes and oxidative parameters in brain and liver tissues have been evaluated. Aluminum was injected for 3 weeks and from the beginning of the third week, FC60 NPs were injected for 1 week. Results: Administration of FC60 NPs showed a significant improvement in the altered activity level of the selected markers. Conclusion: Results suggest synthesized FC60 NPs as a therapeutic option for the treatment of neurodegenerative diseases.
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