CYP1A1 common gene polymorphisms and ischemic stroke risk: a meta-analysis and a structural examination

Area of Science:

• Genetics
• Cardiovascular Science
• Pharmacogenomics

Background:

• Ischemic stroke is a leading cause of death and disability worldwide.
• Genetic variations in metabolizing enzymes like Cytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) may influence stroke risk.
• Polymorphisms in CYP1A1 have been investigated for their association with various diseases.

Approach:

• A meta-analysis was performed on six eligible studies to assess the association of CYP1A1 polymorphisms (rs4646903 and rs1048943) with ischemic stroke risk.
• Bioinformatic tools were utilized to analyze the potential functional impact of these polymorphisms on CYP1A1 gene expression and protein function.
• Systematic literature search and rigorous screening procedures were employed to ensure the quality of included studies.

Key Points:

• The rs4646903 polymorphism in CYP1A1 was significantly associated with a reduced risk of ischemic stroke.
• No significant association was found between the rs1048943 polymorphism and ischemic stroke risk.
• In silico analysis indicated that rs4646903 may affect gene expression, while rs1048943 could impact cofactor affinity.

Conclusions:

• The CYP1A1 rs4646903 polymorphism may act as a protective genetic factor against ischemic stroke.
• Further research is warranted to elucidate the precise mechanisms by which CYP1A1 polymorphisms influence stroke susceptibility.
• These findings contribute to understanding the genetic underpinnings of ischemic stroke and may inform personalized medicine approaches.