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Updated: Jul 30, 2025

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
Published on: June 20, 2019
Efficient Access to Sequence-Controlled Poly(α-hydroxy acids) with A(BC)D-Type and A(BC)A-Type Triblock Structures
Zhaowei Jia1, Xiaofei Zhang1, Ji Xian1
1State Key Laboratory of Applied Organic Chemistry (Lanzhou University), Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
Abstract:
Synthesizing block-sequence-controlled poly(α-hydroxy acids) of three or four α-hydroxy acids remains challenging in one step. In this study, a strategy was employed using three monomers of O-carboxyanhydrides (OCAs) consisting of one α-hydroxy acid (A), asymmetric cyclic diester (B and C, two different α-hydroxy acids of B and C), and symmetric cyclic diester (one α-hydroxy acid of D) with remarkably different activities toward a stereoselective, regioselective, and chemoselective initiator of a zirconium complex. Then, via a self-switchable approach, these monomers can be copolymerized in a well-controlled block sequence of A(BC)D and A(BC)A without an external stimulus. Moreover, upon addition of more monomer mixtures during the copolymerization process, more complicated sequence-controlled poly(α-hydroxy acids) can be achieved with up to 15 blocks.
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