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Pilonidal sinus disease carcinoma: Survival and recurrence analysis
Mhd Firas Safadi1,2, Konstantinos Degiannis3, Dietrich Doll2,4
1Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.
Journal of Surgical Oncology
|May 17, 2023
Summary
Pilonidal sinus carcinoma (PSD) has a poor prognosis, with a 5-year survival rate of 59.8%. Advanced stage and poor differentiation are linked to worse outcomes and higher recurrence rates.
Area of Science:
- Oncology
- Dermatology
- Surgical Pathology
Background:
- Pilonidal sinus disease (PSD) is a chronic condition that can rarely develop into squamous cell carcinoma.
- Understanding the prognosis of PSD carcinoma is crucial for patient management.
Purpose of the Study:
- To determine the survival and recurrence rates of pilonidal sinus disease (PSD) carcinoma.
- To identify prognostic factors influencing outcomes in PSD carcinoma.
Main Methods:
- A retrospective literature search was conducted for all reported cases of carcinoma arising in PSD.
- Data from 140 cases published between 1900 and 2022 were analyzed.
- Kaplan-Meier curves were used to present survival data.
Main Results:
- Squamous cell carcinoma was the predominant type (94.6%).
- The 5-year disease-specific survival rate was 59.8%, with significant differences based on tumor stage and grade.
- Recurrence was observed in 46.6% of patients, with local recurrence being most common.
Conclusions:
- Pilonidal sinus carcinoma carries a poorer prognosis compared to primary cutaneous squamous cell carcinoma.
- Advanced stage at diagnosis and poor tumor differentiation are significant negative prognostic factors.
Keywords:
Marjolin's ulcerinfection degenerationpilonidal sinus carcinomapilonidal sinus diseasesquamous cell carcinomasurvival analysisMore Related Videos
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