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CCN proteins: opportunities for clinical studies-a personal perspective
1Developmental and Stem Cell Biology, Research Institute, SickKids, University of Toronto, Toronto, ON, Canada. hermie@sickkids.ca.
Journal of Cell Communication and Signaling
|May 17, 2023
Summary
The CCN protein family, including CCN1-6, are key regulators in cellular processes and disease. This review highlights their roles in cancer and non-cancer conditions, suggesting potential therapeutic applications.
Area of Science:
- Biochemistry
- Cell Biology
- Molecular Biology
Background:
- The CCN (Cell-Engaging Network) family comprises conserved matricellular proteins (CCN1-6) with diverse functions across all organs.
- These proteins interact with cell receptors like integrins, initiating intracellular signaling cascades.
- CCN proteins can be proteolytically cleaved, with active fragments translocating to the nucleus for transcriptional regulation.
Purpose of the Study:
- To review recent evidence on CCN proteins in cancer and non-cancer diseases.
- To explore the potential of CCN proteins as disease biomarkers and homeostatic regulators.
- To discuss potential therapeutic strategies and clinical applications based on CCN protein functions.
Main Methods:
- Literature review of recent scientific evidence on CCN proteins.
- Analysis of CCN protein roles in cancer and non-cancer pathologies.
- Evaluation of the feasibility of therapeutic approaches targeting CCN proteins.
Main Results:
- CCN proteins exhibit a wide range of functions, with some members acting antagonistically to maintain balance.
- These secreted proteins are quantifiable in circulation and show promise as disease biomarkers.
- Emerging evidence suggests CCN proteins play roles in homeostasis, with potential implications for therapeutic interventions.
Conclusions:
- CCN proteins are crucial regulators with significant roles in both normal physiology and disease states.
- Their involvement in cancer and other conditions presents opportunities for novel biomarker development and therapeutic strategies.
- Further research into CCN protein functions and interactions is warranted for clinical advancement.
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