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Published on: October 13, 2023
Sjögren's syndrome
Geza Balint1, W Watson Buchanan2, Colin A Kean3
13rd Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Frankel Leó út 27-29, Budapest, 1023, Hungary.
Sjögren's syndrome causes dry eyes and dry mouth. This autoimmune condition can be primary or secondary, linked to other diseases like rheumatoid arthritis or infections such as hepatitis C.
Area of Science:
- Autoimmune diseases
- Rheumatology
- Immunology
Background:
- Sjögren's syndrome (SS) is an autoimmune disorder.
- Primary SS presents with dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia), often with salivary gland enlargement.
- Secondary SS occurs alongside other connective tissue diseases (e.g., rheumatoid arthritis, lupus) or conditions like HIV, hepatitis C, and fibromyalgia.
Purpose of the Study:
- To define the characteristics and associations of Sjögren's syndrome.
Main Methods:
- Literature review and synthesis of existing data on Sjögren's syndrome.
- Classification of primary and secondary Sjögren's syndrome.
- Identification of associated conditions and diseases.
Main Results:
- Sjögren's syndrome is characterized by specific symptoms like dry eyes and dry mouth.
- Primary SS is defined by these core symptoms.
- Secondary SS is identified when co-occurring with other autoimmune or chronic conditions.
Conclusions:
- Sjögren's syndrome encompasses a range of clinical presentations.
- Understanding the primary and secondary forms aids in diagnosis and management.
- SS is linked to a diverse spectrum of systemic diseases and infections.
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