Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gross Anatomy of the Lungs

Gross Anatomy of the Lungs

The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

TGF-alpha/EGFR signalling mediates retinoic acid-induced lung repair.

NPJ Regenerative medicine·2026

Same author

A human PCLS model of lung injury and repair for discovery and pharmaceutical research.

Respiratory research·2025

Same author

Precision-Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research: An Official American Thoracic Society Workshop Report.

American journal of respiratory cell and molecular biology·2024

Same author

A Novel Method for Floxed Gene Manipulation Using TAT-Cre Recombinase in Ex Vivo Precision-Cut Lung Slices (PCLS).

Bio-protocol·2024

Same author

Deciphering the impacts of modulating the Wnt-planar cell polarity (PCP) pathway on alveolar repair.

Frontiers in cell and developmental biology·2024

Same author

Extracellular Matrix as a Driver of Chronic Lung Diseases.

American journal of respiratory cell and molecular biology·2024

Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026

Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026

Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026

Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026

Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026

Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 30, 2025

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Simple Models of Lung Development.

Charlotte H Dean¹, Sek-Shir Cheong²

¹National Heart and Lung Institute, Imperial College London, London, UK. c.dean@imperial.ac.uk.

Advances in Experimental Medicine and Biology

|May 17, 2023

Summary

This summary is machine-generated.

Understanding lung development requires various models. This chapter reviews simple in vitro, in silico, and ex vivo models, detailing their developmental stages, advantages, and limitations for lung disease research.

Keywords:

Embryonic Ex vivo model In utero Lung development

More Related Videos

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

Mouse Pneumonectomy Model of Compensatory Lung Growth

Mouse Pneumonectomy Model of Compensatory Lung Growth

Published on: December 17, 2014

Related Experiment Videos

Last Updated: Jul 30, 2025

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

Mouse Pneumonectomy Model of Compensatory Lung Growth

Mouse Pneumonectomy Model of Compensatory Lung Growth

Published on: December 17, 2014

Area of Science:

Pulmonology
Developmental Biology
Biomedical Engineering

Background:

Models are crucial for studying lung development and regeneration.
Effective models aid in identifying and testing treatments for lung diseases.
Existing models recapitulate specific stages of lung development.

Purpose of the Study:

To describe simple in vitro, in silico, and ex vivo models of lung development.
To define the developmental stages recapitulated by each model.
To highlight the advantages and disadvantages of these models.

Main Methods:

Review of existing literature on lung development models.
Categorization of models based on complexity (in vitro, in silico, ex vivo).
Analysis of model capabilities in recapitulating lung development stages.

Main Results:

Identification of various simple models for lung development research.
Characterization of the specific developmental stages each model represents.
Summary of the pros and cons for each model type.

Conclusions:

Simple in vitro, in silico, and ex vivo models offer valuable tools for studying lung development.
Each model type has specific strengths and weaknesses that influence its application.
These models facilitate research into lung diseases and potential therapeutic interventions.