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A tetranuclear polypyridylruthenium(II) complex as a selective stain for extracellular vesicle penetration through
Kartika Wardhani1, Aviva Levina1, Biyun Sun2
1School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia. peter.lay@sydney.edu.au.
Abstract:
A new photoluminescent polypyridylruthenium(II) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.
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