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Updated: Jul 30, 2025

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
Published on: February 3, 2018
Recent progress of TP/NIR fluorescent probes for metal ions
Yahui Chen1, Shiyue Zheng2, Myung Hwa Kim1
1Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, South Korea; New and Renewable Energy Research Center, Ewha Womans University, Seoul, 03760, South Korea.
Abstract:
Metal ions are of significance in various pathological and physiological processes. As such, it is crucial to monitor their levels in organisms. Two-photon (TP) and near-infrared (NIR) fluorescence imaging has been utilized to monitor metal ions because of minimal background interference, deeper tissue depth penetration, lower tissue self-absorption, and reduced photodamage. In this review, we briefly summarize recent progress from 2020 to 2022 of TP/NIR organic fluorescent probes and inorganic sensors in the detection of metal ions. Additionally, we present an outlook for the development of TP/NIR probes for bio-imaging, diagnosis of diseases, imaging-guided therapy, and activatable phototherapy.

