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Role of MAGI2-AS3 in malignant and non-malignant disorders
Mohammad Taheri1, Arian Askari2, Bashdar Mahmud Hussen3
1Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Abstract:
MAGI2 Antisense RNA 3 (MAGI2-AS3) is a long non-coding RNA (lncRNA) transcribed from a locus on 7q21.11. This lncRNA has been described to be abnormally expressed in a variety of malignancies in correlation with many clinical characteristics. Moreover, it might participate in the pathogenesis of congenital diaphragmatic hernia, Alzheimer's disease and intervertebral disc degeneration. Mechanistically, MAGI2-AS3 can serve as a molecular sponge for miR-142-3p, miR-424-5p, miR-15b, miR-233, miR-452-5p, miR-629-5p, miR-25, miR-155, miR-23a-3p, miR-519c-3p, miR-374b-5p, miR-374a, miR-31-5p, miR-3163, miR-525-5p, miR-15-5p, miR-374a-5p, miR-374b-5p, miR-218-5p, miR-141-3p and miR-200a-3p to regulate expression of their mRNA targets. The current review summarizes the role of MAGI2-AS3 in different disorders to highlight its importance in their pathophysiology.
Insights
MAGI2 Antisense RNA 3 (MAGI2-AS3), a long non-coding RNA, is linked to various cancers and diseases. It acts as a molecular sponge, regulating gene expression and impacting pathophysiology.
Area of Science:
- Genetics
- Molecular Biology
- RNA Biology
Background:
- MAGI2 Antisense RNA 3 (MAGI2-AS3) is a long non-coding RNA (lncRNA) located at 7q21.11.
- Abnormal MAGI2-AS3 expression is observed in various malignancies, correlating with clinical features.
- MAGI2-AS3 is implicated in the pathogenesis of congenital diaphragmatic hernia, Alzheimer's disease, and intervertebral disc degeneration.
Purpose of the Study:
- To review the multifaceted roles of MAGI2-AS3 in different disorders.
- To elucidate the mechanistic involvement of MAGI2-AS3 in disease pathophysiology.
- To highlight the significance of MAGI2-AS3 as a potential therapeutic target.
Main Methods:
- Literature review of studies investigating MAGI2-AS3 expression and function.
- Analysis of MAGI2-AS3's role as a molecular sponge for microRNAs (miRNAs).
- Examination of MAGI2-AS3's regulatory interactions with mRNA targets.
Main Results:
- MAGI2-AS3 acts as a molecular sponge for numerous miRNAs, including miR-142-3p, miR-424-5p, and miR-15b.
- It regulates the expression of target mRNAs, influencing cellular processes.
- Dysregulation of MAGI2-AS3 is associated with diverse pathological conditions.
Conclusions:
- MAGI2-AS3 plays a significant role in the pathophysiology of multiple diseases.
- Its function as a miRNA sponge is a key mechanism underlying its involvement in disease.
- Further research into MAGI2-AS3 could reveal novel therapeutic strategies.
