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Related Experiment Video

Updated: Jul 30, 2025

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Single-cell profiling in multiple myeloma: insights, problems, and promises.

Mehmet Kemal Samur1,2, Raphael Szalat3, Nikhil C Munshi4,5

  • 1Department of Data Science, Dana-Farber Cancer Institute, Boston, MA.

Blood
|May 17, 2023
PubMed
Summary

Single-cell profiling reveals insights into multiple myeloma (MM) complexity, including clonal evolution and drug resistance. This technology is crucial for understanding MM pathogenesis and the tumor microenvironment.

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Area of Science:

  • Hematology
  • Oncology
  • Genomics

Background:

  • Single-cell platforms are increasingly vital in multiple myeloma (MM) research due to significant cellular heterogeneity.
  • Bulk assessments in MM can overlook crucial data on cellular subpopulations and cell-to-cell interactions.
  • Advancements in single-cell technologies, multiomics, and computational analysis enhance MM research capabilities.

Conclusions:

  • Single-cell profiling is indispensable for dissecting the complexity of multiple myeloma.
  • Continued application of these technologies promises further breakthroughs in MM pathogenesis and treatment.
  • Further research is needed to fully leverage single-cell data for therapeutic strategies.