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Cell-based relay delivery strategy in biomedical applications.

Yu Chen1, Samira Pal2, Quanyin Hu1

  • 1Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, United States; Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States; Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, United States.

Advanced Drug Delivery Reviews
|May 17, 2023
PubMed
Summary
This summary is machine-generated.

This review explores relay delivery strategies for targeted therapies. Cellular products act as initiators or effectors, enhancing drug accumulation at disease sites for improved treatment efficacy.

Keywords:
Active targetingBioengineeringBiomaterialsCell therapyChemical modificationRelay drug delivery

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Area of Science:

  • Biomedical Engineering
  • Drug Delivery
  • Cellular Therapeutics

Background:

  • Targeted drug delivery aims to increase therapeutic efficacy while minimizing side effects.
  • Conventional delivery systems face challenges in achieving efficient accumulation at target sites.
  • Cell-based therapeutics offer unique homing and modification capabilities for advanced delivery.

Purpose of the Study:

  • To review recent advancements in relay delivery strategies.
  • To highlight the role of cellular products in relay delivery systems.
  • To explore the potential of cells as initiators and effectors in targeted therapies.

Main Methods:

  • Literature review of relay delivery strategies.
  • Analysis of cell-based approaches in targeted delivery.
  • Focus on initiator and effector modules in cellular relay systems.

Main Results:

  • Relay delivery enhances signal amplification and accumulation efficiency at disease sites.
  • Cells can be engineered as effective initiators or effectors in relay systems.
  • Cellular properties facilitate specific interactions with biological environments.

Conclusions:

  • Relay delivery strategies, particularly those utilizing cellular components, show significant promise for targeted therapies.
  • The dual-module approach optimizes drug accumulation and therapeutic outcomes.
  • Further research into cell-based relay systems can unlock new treatment paradigms.