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The pyroptotic role of Caspase-3/GSDME signalling pathway among various cancer: A Review

Asif Ahmad Bhat1, Riya Thapa1, Obaid Afzal2

  • 1School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India.

International Journal of Biological Macromolecules
|May 17, 2023
PubMed

Insights

Pyroptosis, a programmed cell death, inhibits cancer cell proliferation and tumor growth. Caspase-3 and gasdermin E (GSDME) are key regulators of pyroptosis and may be promising therapeutic targets for cancer treatment.

Area of Science:

  • Cellular biology
  • Molecular mechanisms of cell death
  • Cancer research

Background:

  • Cytotoxic drugs induce cancer cell death via apoptosis.
  • Pyroptosis is another programmed cell death pathway that inhibits cell proliferation and shrinks tumors.
  • Both pyroptosis and apoptosis are caspase-dependent processes.

Purpose of the Study:

  • To investigate the role of pyroptosis in cancer.
  • To understand the cellular and molecular mechanisms of caspase-3 and gasdermin E (GSDME) mediated programmed cell death.
  • To explore caspase-3 and GSDME as potential therapeutic targets for cancer treatment.

Main Methods:

  • Focus on pyroptosis mechanisms.
  • Analysis of inflammasome activation, caspase-1, and cytokine cleavage (IL-1β, IL-18).
  • Investigated gasdermin E (GSDME) cleavage and its role in pyroptosis.

Main Results:

  • Pyroptosis inhibits cancer cell proliferation and tumor growth.
  • Gasdermin proteins, including GSDME, are crucial for pyroptosis.
  • Activated caspase-3 cleaves GSDME, leading to cell membrane pore formation and cell death.

Conclusions:

  • Caspase-3 and GSDME are central to pyroptosis.
  • These proteins are implicated in tumor genesis, development, and response to therapy.
  • Caspase-3 and GSDME represent promising therapeutic targets for cancer treatment.
Keywords:
ApoptosisCancerCaspase-3GSDMEProgrammed cell deathPyroptosis

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