Related Experiment Video
Updated: Jul 30, 2025

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
Published on: March 1, 2024
Vulvovaginal Complaints as the First Manifestation of Crohn's Disease in Children: Case Report
Xiomara B Brioso1, Darnna Banks2, Emily Christison-Lagay3
1Department of Obstetrics, Gynecology and Reproductive Sciences, Yale New Haven Hospital, New Haven, Connecticut.
Insights
Pediatric Crohn's disease can manifest as gynecological issues like rectolabial fistulas. Early collaboration ensures prompt diagnosis and treatment for better outcomes in children.
Area of Science:
- Pediatric Gastroenterology
- Pediatric Gynecology
- Inflammatory Bowel Disease Research
Background:
- Crohn's disease (CD) is a chronic inflammatory condition impacting the gastrointestinal tract.
- Gynecological structures can be involved in pediatric CD, with rectovaginal or rectovestibular manifestations often presenting as initial signs.
Observation:
- A 9-year-old premenarchal female presented with chronic constipation, poor growth, and persistent vulvovaginal discharge/irritation.
- Examination revealed a rectolabial fistula, leading to a diagnosis of Crohn's disease via colonoscopy.
Findings:
- The patient's rectolabial fistula, a gynecological manifestation, was indicative of underlying Crohn's disease.
- Immunotherapy led to symptom improvement and positive anatomical changes in the affected child.
Implications:
- Persistent vulvar complaints in children necessitate considering non-gynecological diagnoses, including Crohn's disease.
- Multidisciplinary collaboration among pediatric gynecologists, gastroenterologists, and surgeons is crucial for timely diagnosis and management of genital Crohn's disease.
Background:
Crohn's disease, a chronic gastrointestinal inflammatory condition, can involve gynecological structures. Rectovaginal or rectovestibular involvement may be the first sign in the pediatric population and may result in delayed diagnosis and treatment.
Case:
A 9-year-old premenarchal female with chronic constipation and poor growth presented to the pediatric gynecologist for evaluation of persistent vulvovaginal discharge and vulvar irritation. Examination under anesthesia revealed a rectolabial fistula; colonoscopy was diagnostic of Crohn's disease. Immunotherapy resulted in improvement of symptoms and anatomical changes.
Summary And Conclusion:
In cases of persistent vulvar complaints in a child without clear diagnosis, a high index of suspicion for a non-gynecologic diagnosis is necessary. Collaboration between pediatric gynecologists, gastroenterologists, and surgeons can result in prompt diagnosis and treatment of genital Crohn's disease.
Related Concept Videos
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.

