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Updated: Jul 30, 2025

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
Published on: April 4, 2016
Circular mixed sets
Elena Fimmel1, Christian J Michel2, Lutz Strüngmann1
1Institute of Mathematical Biology, Faculty for Computer Sciences, Mannheim University of Applied Sciences, 68163 Mannheim, Germany.
Abstract:
In this article, we introduce the new mathematical concept of circular mixed sets of words over an arbitrary finite alphabet. These circular mixed sets may not be codes in the classical sense and hence allow a higher amount of information to be encoded. After describing their basic properties, we generalize a recent graph theoretical approach for circularity and apply it to distinguish codes from sets (i.e. non-codes). Moreover, several methods are given to construct circular mixed sets. Finally, this approach allows us to propose a new evolution model of the present genetic code that could have evolved from a dinucleotide world to a trinucleotide world via circular mixed sets of dinucleotides and trinucleotides.
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