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Updated: Jul 30, 2025
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
STAT5A modulates gastric cancer progression via upregulation of CD44
Shanglin Wang1, Rong Fan2, Huayu Gao3
1Research Center of Basic Medicine, Jinan Central Hospital, Shandong University, 56# Shanda South Road, Jinan, Shandong 250013, People's Republic of China; Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, 16766# Jingshi Road, Jinan, Shandong 250014, People's Republic of China; Research Center of Basic Medicine, Jinan Central Hospital, Shandong First Medical University, 56# Shanda South Road, Jinan, Shandong 250013, People's Republic of China.
Objective:
Signal transduction and transcriptional activator 5A (STAT5A), which has been reported to be frequently phosphorylated in tumors, plays pivotal roles in tumor progression. However, the role of STAT5A in gastric cancer (GC) progression and the downstream targets of STAT5A remain largely unknown.
Methods:
The expression of STAT5A and CD44 were assessed. GC cells were treated with altered STAT5A and CD44 to evaluate their biological functions. Nude mice were given injections of genetically manipulated GC cells and growth of xenograft tumors and metastases was measured.
Results:
The increased level of p-STAT5A is associated with tumor invasion and poor prognosis in GC. STAT5A promoted GC cell proliferation by upregulating CD44 expression. STAT5A directly binds to the CD44 promoter and promotes its transcription.
Conclusions:
The STAT5A/CD44 pathway plays a critical role in GC progression, promising potential clinical applications for improving treatment of GC.
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