Related Experiment Video
Updated: Jul 30, 2025
07:35
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
7.0K
Colorectal Cancer Diagnostic Methods: The Present and Future
Sai Sravya Gude1, Rithik S Veeravalli2, Bhuvanasai Vejandla3
1Oncology, University of Houston, Houston, USA.
Cureus
|May 17, 2023
Summary
Colorectal cancer (CRC) screening guidelines now recommend starting at age 45. This overview discusses current stool-based and visual inspection tests, alongside emerging AI and genetic diagnostics for CRC detection.
Area of Science:
- Oncology
- Gastroenterology
- Medical Diagnostics
Background:
- Colorectal cancer (CRC) screening is evolving to meet patient needs.
- Current guidelines advise average-risk individuals to commence CRC screening at age 45.
- Existing screening methods face validation challenges for precursor lesion detection.
Purpose of the Study:
- To review current colorectal cancer (CRC) diagnostic tests.
- To discuss emerging AI and genetic-based diagnostic innovations in CRC screening.
- To highlight the need for validation of new CRC diagnostic technologies.
Main Methods:
- Categorization of CRC tests into stool-based assays and visual inspections.
- Description of established stool-based tests: guaiac-based fecal occult blood testing, fecal immunochemical testing, and multitarget stool DNA testing.
- Overview of visualization examinations: colon capsule endoscopy and flexible sigmoidoscopy.
Main Results:
- CRC screening tests are broadly divided into stool-based and visual inspection categories.
- Established tests include fecal occult blood testing, fecal immunochemical testing, stool DNA testing, colon capsule endoscopy, and flexible sigmoidoscopy.
- Newer diagnostic tests leveraging AI and genetics are under development.
Conclusions:
- The landscape of colorectal cancer (CRC) screening is dynamic, with updated age recommendations.
- While current tests exist, validation remains a concern for precursor lesion management.
- Emerging AI and genetic technologies offer promising avenues for future CRC diagnostics, requiring further validation.
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