Intracranial Extra-axial Undifferentiated Pleomorphic Sarcoma; a Case Report

Area of Science:

• Neuro-oncology
• Soft-tissue sarcoma research
• Medical imaging in oncology

Background:

• Head-and-neck sarcomas are aggressive malignancies with high mortality rates.
• Undifferentiated pleomorphic sarcoma (UPS) is a high-grade soft-tissue tumor typically found in limbs and retroperitoneal cavities.
• Intracranial soft-tissue sarcomas are rare but can occur as primary lesions within the brain.

Observation:

• A young male presented with occipital headache and blurred vision.
• Imaging revealed an extra-axial intracranial mass with specific characteristics on CT and MRI.
• Histopathology confirmed the diagnosis of UPS after surgical excision.

Findings:

• The patient underwent successful surgical resection of the intracranial UPS.
• Post-operative imaging showed no residual disease.
• The patient remained asymptomatic for over two years post-surgery.

Implications:

• Differentiating intracranial soft-tissue sarcomas from other extra-axial tumors requires understanding clinical and radiological features.
• Surgical excision, radiotherapy, and regular follow-ups are crucial for managing intracranial sarcomas.
• Prompt tissue sampling and staging scans are essential for accurate diagnosis and treatment planning.