Related Experiment Video

Updated: Jul 30, 2025

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

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Novel Treatments for Patients With Relapsed/Refractory Multiple Myeloma

Cesar Rodriguez1, Donna Catamero1

  • 1From Mount Sinai School of Medicine, New York, New York.

Journal of the Advanced Practitioner in Oncology
|May 17, 2023
PubMed

Insights

Multiple myeloma treatment has advanced, but the incurable disease often becomes refractory. Strategies are needed to manage treatment resistance and complications in relapsed/refractory multiple myeloma.

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Multiple myeloma is an incurable plasma cell malignancy with increasing therapeutic options.
  • Relapsed/refractory multiple myeloma presents challenges due to genetic alterations driving treatment resistance.
  • Subsequent therapies often yield progressively shorter remission durations.

Purpose of the Study:

  • To discuss the multifactorial approach in selecting optimal therapies for individual patients with relapsed/refractory multiple myeloma.
  • To outline strategies for managing unique treatment complications associated with novel therapeutic modalities.

Main Methods:

  • Expert discussions and presentations at JADPRO Live 2022.
  • Review of current therapeutic landscape for multiple myeloma.
  • Analysis of treatment resistance mechanisms and complications.

Main Results:

  • Therapeutic options for multiple myeloma have significantly expanded.
  • Relapsed/refractory disease is characterized by genetic drivers of resistance.
  • Management requires a personalized approach considering patient-specific factors and novel treatment complications.

Conclusions:

  • Despite advances, multiple myeloma remains incurable, necessitating tailored treatment strategies.
  • Addressing genetic resistance and managing complications are critical for improving outcomes in relapsed/refractory multiple myeloma.
  • Personalized therapy selection and proactive complication management are key.

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