Related Experiment Video

Updated: Jul 30, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.2K

Updating the Targeted Therapy Paradigm for Patients With Metastatic NSCLC

Narjust Florez Duma1, Stephanie Mcdonald1

  • 1From Dana-Farber Cancer Institute, Boston, Massachusetts.

Journal of the Advanced Practitioner in Oncology
|May 17, 2023
PubMed

Insights

Targeted therapy has transformed metastatic non-small cell lung cancer treatment. JADPRO Live 2022 highlighted updated guidelines, biomarker-driven therapies, and managing treatment side effects for improved patient care.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Practice

Background:

  • Metastatic non-small cell lung cancer (NSCLC) treatment has evolved.
  • Targeted therapies represent a significant advancement in NSCLC management.

Purpose of the Study:

  • To summarize key updates in metastatic NSCLC treatment presented at JADPRO Live 2022.
  • To discuss recent clinical trial data on biomarkers and targeted therapies.
  • To outline best practices for managing adverse events associated with targeted NSCLC therapies.

Main Methods:

  • Review of presentations from JADPRO Live 2022.
  • Focus on clinical practice guideline updates.
  • Analysis of recent clinical trial data for biomarker-targeted therapy combinations.

Main Results:

  • Significant changes in the NSCLC treatment paradigm due to targeted therapy.
  • Emphasis on biomarker identification for personalized treatment selection.
  • Importance of proactive side effect monitoring and management.

Conclusions:

  • Targeted therapies are revolutionizing metastatic NSCLC care.
  • Adherence to updated guidelines and managing side effects are crucial.
  • Ongoing research in biomarkers and novel therapies continues to advance treatment outcomes.

More Related Videos

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

4.1K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.3K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
584
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K