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Related Concept Videos

Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Related Experiment Video

Updated: Jul 30, 2025

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
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Same but different: how agency modulates pain perception.

Katja Wiech1

  • 1Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Trends in Cognitive Sciences
|May 17, 2023
PubMed
Summary
This summary is machine-generated.

Self-administering pain relief enhances treatment effectiveness by shifting expectations, not by reducing uncertainty. This agency effect profoundly impacts the entire perceptual process of pain management.

Keywords:
active inferenceagencylikelihoodpainprecisionprior

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Area of Science:

  • Cognitive Neuroscience
  • Perception Science
  • Pain Management

Background:

  • Analgesic treatment effectiveness can vary based on administration method.
  • Self-administration of pain relief is often perceived as more effective than passive administration.

Purpose of the Study:

  • To investigate the underlying mechanisms behind the enhanced effectiveness of self-administered analgesic treatment.
  • To compare two proposed accounts for the effect of agency on perceptual outcomes.

Main Methods:

  • The study compared two theoretical accounts of agency's influence on perception.
  • Experimental design likely involved comparing self-administration versus passive administration of a placebo or mild analgesic.

Main Results:

  • The effect of agency on pain perception was found to be linked to a shift in expectation (prior).
  • This effect was not attributable to reduced likelihood precision, indicating a distinct mechanism.

Conclusions:

  • Agency profoundly influences the entire perceptual process, particularly in the context of pain management.
  • Shifts in prior expectations, driven by self-administration, are key to enhanced analgesic treatment effectiveness.