Efficacy of intraoperative intravenous lidocaine infusion on postoperative opioid consumption after laparoscopic cholecystectomy: a randomized controlled trial
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Published on: June 25, 2013
Chamaidi Sarakatsianou1, Konstantinos Perivoliotis2, Ioannis Baloyiannis3
1Department of Anaesthesiology, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece. heidisarak@gmail.com.
Purpose:
We designed this study to evaluate the impact of intraoperative intravenous lidocaine infusion on postoperative opioid consumption after laparoscopic cholecystectomy.
Methods:
In total, 98 patients scheduled for elective laparoscopic cholecystectomy were included and randomized. In the experimental group, intravenous lidocaine (bolus 1.5 mg/kg and continuous infusion 2 mg/kg/h) was administered intraoperatively additionally to the standard analgesia, whereas the control group received a matching placebo. Blinding existed at the level of both the patient and the investigator.
Results:
Our study failed to confirm any benefit in opioid consumption, during the postoperative period. Lidocaine resulted to reduced intraoperative systolic, diastolic, and mean arterial pressure. Lidocaine administration did not change postoperative pain scores or the incidence of shoulder pain, at any time endpoint. Moreover, we did not identify any difference in terms of postoperative sedation levels and nausea rates.
Conclusion:
Overall, lidocaine did not have any effect on postoperative analgesia after laparoscopic cholecystectomy.
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