Fertility study of rifaximin (L/105) in rats

The influence of rifaximin (L/105) on conception and pregnancy in rats up to F1 progeny was reported. Rifaximin showed a good fertility rate and no dose-related differences in the number of viable or dead fetuses per litter (Fo progeny) up to 100 mg/kg. The number of live or dead pups at birth, pup weight, gestation length and survival of offspring to weaning were not influenced up to the highest dose, 100 mg/kg (Fo-F1 progeny).