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Updated: Jul 30, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Updates in treatment and impact of nail psoriasis
Matilde Iorizzo1, Antonella Tosti2
1Private Dermatology Practice, Bellinzona/Lugano, Switzerland.
Insights
Nail psoriasis significantly impacts quality of life and is difficult to treat. This review updates on new treatments and highlights gaps in current nail psoriasis care.
Area of Science:
- Dermatology
- Rheumatology
Background:
- Nail psoriasis is an inflammatory condition impacting patient quality of life and is linked to psoriatic arthritis.
- Early onset of nail psoriasis may predict severe adult disease and contributes to the economic burden of psoriasis.
Purpose of the Study:
- To provide an update on novel therapeutic strategies for nail psoriasis.
- To identify and address current unmet needs in the management of nail psoriasis.
Main Methods:
- Literature review of recent advancements in nail psoriasis treatment.
- Analysis of current therapeutic guidelines and clinical trial data.
Main Results:
- New treatments for nail psoriasis are emerging, offering improved management options.
- Significant gaps persist in nail psoriasis care, necessitating further research and standardized trial methodologies.
Conclusions:
- Enhanced understanding of disease pathogenesis and real-world studies are crucial for optimizing nail psoriasis treatment outcomes.
- Further unbiased research is needed to clarify the association between nail psoriasis and psoriatic arthritis risk.
Introduction:
Nail psoriasis is an inflammatory disorder without a potential scarring outcome, but the nail signs, even the milder ones, can cause discomfort to patients and severely affect their quality of life. Nail psoriasis may be associated with psoriatic arthritis and when it starts during infancy, it may be a predictor of a more severe disease course in adulthood. All these issues contribute to the high economic burden of psoriasis.
Areas Covered:
Nail psoriasis is notoriously difficult to treat, even though new treatments are in continuous development. This paper provides an update on new treatments and address the current gaps in care of nail psoriasis.
Expert Opinion:
A better understanding of the disease pathogenesis and more 'real-life' studies will definitely be helpful to improve treatment results. A lower level of heterogeneity should be advisable among trials when evaluating nail psoriasis. Moreover, the relationship between nail psoriasis and psoriatic arthritis should be the focus of unbiased studies in order to better define the real risk that nail psoriasis patients have to develop arthritis.
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