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Related Experiment Videos

Morphine depression of myocardial function.

T R Riggs, Y Yano, T Vargish

    Circulatory Shock
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Opiate receptors are present in the heart muscle, and morphine sulfate directly impacts heart function. This study demonstrates morphine sulfate

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Physiology

    Background:

    • Opiate receptors are known to exist in the central nervous system and peripheral tissues.
    • The direct effect of opiates on myocardial function, independent of neuronal and humoral influences, requires further investigation.
    • Understanding endogenous opiate roles in cardiovascular regulation, particularly during shock, is crucial.

    Purpose of the Study:

    • To establish the presence of opiate receptors within the myocardium.
    • To investigate the direct effects of an opiate agonist, morphine sulfate, on isolated working rat heart function.
    • To elucidate the potential mechanisms of endogenous opiates in cardiovascular regulation.

    Main Methods:

    • Utilized a modified Langendorff preparation for isolated working rat hearts.

    Related Experiment Videos

  • Administered varying concentrations of morphine sulfate (2 x 10(-4) M and 3 x 10(-4) M) in Krebs-Henseleit Buffer.
  • Monitored heart rate (HR), cardiac output (CO), and aortic dP/dtmax under controlled temperature, preload, and afterload conditions.

    • Main Results:

    • Demonstrated a significant, dose-related depression of heart rate (HR) and cardiac output (CO).
    • Observed a less significant decrease in aortic dP/dtmax, indicating impaired contractility.
    • These myocardial functional changes were directly attributed to morphine sulfate administration.

    Conclusions:

    • The study confirms the presence of functional opiate receptors in the myocardium.
    • Morphine sulfate acts directly on the heart, causing negative chronotropic and inotropic effects.
    • These findings suggest a potential role for endogenous opiates in modulating cardiac function during physiological stress like shock.