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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Atherosclerosis III: Management01:26

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Myasthenia Gravis: Overview and Treatment01:20

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Related Experiment Video

Updated: Jul 30, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Systemic sclerosis: one year in review 2023.

Marco Di Battista1, Gemma Lepri2, Veronica Codullo3

  • 1Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, and Department of Medical Biotechnologies, University of Siena, Italy.

Clinical and Experimental Rheumatology
|May 18, 2023
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Summary

Systemic sclerosis, a rare connective tissue disease, involves complex pathogenesis and varied symptoms. This review summarizes key 2022 research on its development, organ effects, and therapies.

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Area of Science:

  • Rheumatology
  • Immunology
  • Genetics

Background:

  • Systemic sclerosis is a rare, chronic autoimmune disease.
  • It is characterized by intricate pathogenesis and heterogeneous clinical manifestations.
  • Understanding its complexities is crucial for effective management.

Purpose of the Study:

  • To provide an overview of significant research published in 2022.
  • To highlight advancements in understanding systemic sclerosis pathogenesis.
  • To summarize new insights into organ involvement and treatment strategies.

Main Methods:

  • Literature review of studies published in 2022.
  • Synthesis of findings on systemic sclerosis pathogenesis.
  • Analysis of research on organ-specific manifestations and therapeutic interventions.

Main Results:

  • Key studies in 2022 offered novel insights into the multifactorial pathogenesis of systemic sclerosis.
  • Research highlighted emerging patterns of organ involvement, including cardiovascular and pulmonary systems.
  • New therapeutic approaches and treatment outcomes were reported.

Conclusions:

  • The 2022 literature underscores the complexity of systemic sclerosis.
  • Continued research is vital for unraveling its pathogenesis and improving patient outcomes.
  • Advances in understanding offer hope for more targeted and effective treatments.