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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Updated: Jul 11, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
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Plasmonic nanoparticle-based surface-enhanced Raman spectroscopy-guided photothermal therapy: emerging cancer

Anindita Das1, Hsieh-Chih Tsai2,3,4, Tapas Sen5

  • 1Department of Physics, Nanophotonics Lab, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand, 826004, India.

Nanomedicine (London, England)
|May 18, 2023
PubMed
Summary

This review highlights plasmonic nanoparticles for cancer theranostics, combining surface-enhanced Raman spectroscopy (SERS) imaging with photothermal therapy (PTT). These minimally invasive optical techniques offer precise diagnosis and targeted treatment for improved oncological research.

Keywords:
cancer theranosticsphotothermal therapyplasmonic nanoparticlessurface functionalizationsurface-enhanced Raman spectroscopytoxicity

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Area of Science:

  • Oncological research
  • Biomedical optics
  • Nanomedicine

Background:

  • Optical imaging offers minimally invasive molecular and cellular insights into cancer.
  • Photothermal therapy (PTT) presents a highly specific and noninvasive therapeutic approach.
  • Integrating SERS imaging with PTT shows promise for cancer theranostics.

Purpose of the Study:

  • To review recent advancements in plasmonic nanoparticles for SERS-guided PTT.
  • To explore the fundamental principles of SERS and PTT in medical applications.
  • To provide an updated overview of nanoparticle development for cancer theranostics.

Main Methods:

  • Literature review of recent research on plasmonic nanoparticles.
  • Analysis of surface-enhanced Raman spectroscopy (SERS) principles.
  • Exploration of photothermal therapy (PTT) mechanisms and applications.

Main Results:

  • Plasmonic nanoparticles are crucial for developing effective SERS-guided PTT.
  • SERS provides sensitive molecular detection, while PTT enables targeted thermal ablation.
  • Combined approaches enhance diagnostic accuracy and therapeutic efficacy in cancer treatment.

Conclusions:

  • SERS-guided PTT using plasmonic nanoparticles represents a powerful strategy for cancer theranostics.
  • Further development of these nanoparticles can lead to improved minimally invasive cancer diagnosis and therapy.
  • This integrated approach holds significant potential for future oncological interventions.