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Plasmonic nanoparticle-based surface-enhanced Raman spectroscopy-guided photothermal therapy: emerging cancer
Anindita Das1, Hsieh-Chih Tsai2,3,4, Tapas Sen5
1Department of Physics, Nanophotonics Lab, Indian Institute of Technology (Indian School of Mines), Dhanbad, Jharkhand, 826004, India.
Abstract:
Optical imaging modalities have emerged as a keystone in oncological research, capable of providing molecular and cellular information on cancer with the advantage of being minimally invasive toward healthy tissues. Photothermal therapy (PTT) has shown great potential, with the exceptional advantages of high specificity and noninvasiveness. Combining surface-enhanced Raman spectroscopy (SERS)-based optical imaging with PTT has shown tremendous potential in cancer theranostics (therapeutics + diagnosis). This comprehensive review article provides up-to-date information by exploring recent works focused mainly on the development of plasmonic nanoparticles for medical applications using SERS-guided PTT, including the fundamental principles behind SERS and the plasmon heating effect for PTT.
Insights
This review highlights plasmonic nanoparticles for cancer theranostics, combining surface-enhanced Raman spectroscopy (SERS) imaging with photothermal therapy (PTT). These minimally invasive optical techniques offer precise diagnosis and targeted treatment for improved oncological research.
Area of Science:
- Oncological research
- Biomedical optics
- Nanomedicine
Background:
- Optical imaging offers minimally invasive molecular and cellular insights into cancer.
- Photothermal therapy (PTT) presents a highly specific and noninvasive therapeutic approach.
- Integrating SERS imaging with PTT shows promise for cancer theranostics.
Purpose of the Study:
- To review recent advancements in plasmonic nanoparticles for SERS-guided PTT.
- To explore the fundamental principles of SERS and PTT in medical applications.
- To provide an updated overview of nanoparticle development for cancer theranostics.
Main Methods:
- Literature review of recent research on plasmonic nanoparticles.
- Analysis of surface-enhanced Raman spectroscopy (SERS) principles.
- Exploration of photothermal therapy (PTT) mechanisms and applications.
Main Results:
- Plasmonic nanoparticles are crucial for developing effective SERS-guided PTT.
- SERS provides sensitive molecular detection, while PTT enables targeted thermal ablation.
- Combined approaches enhance diagnostic accuracy and therapeutic efficacy in cancer treatment.
Conclusions:
- SERS-guided PTT using plasmonic nanoparticles represents a powerful strategy for cancer theranostics.
- Further development of these nanoparticles can lead to improved minimally invasive cancer diagnosis and therapy.
- This integrated approach holds significant potential for future oncological interventions.
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