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Dynamically crosslinked thermoresponsive granular hydrogels.

Hung-Pang Lee1, Kathy Xiao Cai1, Ting-Ching Wang2

  • 1Biomedical Engineering, College of Engineering, Texas A&M University, College Station, Texas, USA.

Journal of Biomedical Materials Research. Part A
|May 18, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed novel thermo-responsive granular hydrogels using dynamic covalent bonds and a temperature-sensitive polymer. These advanced biomaterials offer self-healing, injectability, and 3D printing capabilities for enhanced biomedical applications.

Keywords:
3D printingcell deliverydrug deliverydynamic biomaterialsgranular hydrogelsregenerative medicine

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Granular hydrogels are versatile biomaterials for tissue regeneration and drug delivery.
  • Current fabrication methods often require post-processing for crosslinking, limiting applications.
  • Oxidized hyaluronic acid (OHA) is a biocompatible polymer suitable for microgel assembly.

Purpose of the Study:

  • To develop novel granular hydrogels with improved properties for biomedical applications.
  • To overcome limitations of post-processing crosslinking in microgel assembly.
  • To create a shear-thinning, self-healing, and injectable hydrogel system.

Main Methods:

  • Incorporation of thiol-functionalized thermo-responsive polymer into OHA microgel assemblies.
  • Utilizing thiol-aldehyde dynamic covalent bonds for primary crosslinking.
  • Leveraging thermo-responsive polymer phase transition for secondary crosslinking at body temperature.

Main Results:

  • The developed granular hydrogels exhibit shear-thinning and self-healing properties.
  • A two-stage crosslinking system provides injectability, shape stability, and mechanical integrity at body temperature.
  • Aldehyde groups enable sustained drug release, and hydrogels support cell encapsulation and 3D printing without post-processing.

Conclusions:

  • Thermo-responsive granular hydrogels offer a promising platform for advanced biomedical applications.
  • The dual crosslinking strategy enhances material properties for tissue engineering and drug delivery.
  • These hydrogels are suitable for 3D printing and cell delivery, simplifying fabrication processes.