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Different Aspects of Aging in Migraine
Michal Fila1, Elzbieta Pawlowska2, Joanna Szczepanska2
1Department of Developmental Neurology and Epileptology, Polish Mother's Memorial Hospital Research Institute, 93-338 Lodz, Poland.
Aging and Disease
|May 18, 2023
Summary
Migraine prevalence and intensity decrease with age, potentially linked to social aging and oxidative stress. Genetic predispositions may influence who experiences migraine, especially with age-related triggers.
Area of Science:
- Neurology
- Aging Research
- Genetics
Background:
- Migraine exhibits a unique age-dependent pattern, with peak intensity in middle age, decreasing thereafter.
- While evolutionary concepts exist, they don't fully explain migraine's age-related prevalence.
- Migraine pathogenesis involves molecular, cellular, social, and cognitive aging aspects, but causal links and individual susceptibility remain unclear.
Purpose of the Study:
- To review associations between migraine and various aging facets.
- To explore the role of oxidative stress in these associations.
- To hypothesize the influence of predispositions and social aging on migraine prevalence.
Main Methods:
- Narrative/hypothesis review of existing literature.
- Examination of links between migraine and chronological, brain, cellular, stem cell, social, cognitive, epigenetic, and metabolic aging.
- Analysis of oxidative stress's role.
Main Results:
- Migraine intensity and frequency typically decline after age 40.
- Social aging, with its associated stress, shows a similar age-dependence to migraine prevalence.
- Oxidative stress is implicated in both aging and migraine pathogenesis.
Conclusions:
- Migraine likely affects individuals with genetic or acquired predispositions, exacerbated by age-related triggers.
- Social aging may be a significant factor in migraine's age-dependent prevalence and sex differences.
- Further research into social aging mechanisms and their link to migraine predisposition is warranted.
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