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Measurement of the Pressure-volume Curve in Mouse Lungs

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Changes in Lung Volumes with Spirometric Disease Progression in COPD.

Mehrdad Arjomandi^1,2, Siyang Zeng^1,3, Jianhong Chen^1,2

¹San Francisco Veterans Affairs Healthcare System, San Francisco, California, United States.

Chronic Obstructive Pulmonary Diseases (Miami, Fla.)

|May 18, 2023

Summary

Abnormal lung volumes in smokers can predict chronic obstructive pulmonary disease (COPD). Total lung capacity and vital capacity changes indicate risk for developing mild or moderate COPD.

Keywords:

COPD air trapping computed tomography early disease lung volumes

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Published on: January 8, 2019

Area of Science:

Pulmonary Medicine
Radiology
Epidemiology

Background:

Abnormal lung volumes, specifically air trapping, identify smokers at risk for developing spirometric chronic obstructive pulmonary disease (COPD) and adverse outcomes.
The evolution of lung volumes in early COPD as airflow obstruction develops is not well understood.

Purpose of the Study:

To investigate how lung volumes change during the development of spirometric COPD.
To analyze cross-sectional distributions and longitudinal changes in lung volumes across the airflow obstruction spectrum.

Main Methods:

Utilized pulmonary function data from U.S. Department of Veterans Affairs electronic health records (n=71,356).
Analyzed lung volumes from computed tomography scans in the COPD Genetic Epidemiology (COPDGene®) study (n=7969) and SPIROMICS (n=2552) cohorts.
Excluded patients with preserved ratio-impaired spirometry (PRISm).

Main Results:

Lung volume distributions and changes showed similar patterns across all three cohorts with worsening airflow obstruction.
Total lung capacity (TLC), vital capacity (VC), and inspiratory capacity (IC) exhibited nonlinear changes.
Patients with GOLD 1 (mild) COPD had larger TLC, VC, and IC than GOLD 0 or GOLD 2 (moderate) COPD. Baseline higher TLC and VC predicted progression to GOLD 1, while lower values predicted progression to GOLD 2.

Conclusions:

Lung volumes (TLC, VC) in COPD display biphasic distributions and nonlinear changes with increasing obstruction.
Lung volumes can identify GOLD 0 patients at higher risk for accelerated spirometric COPD progression.