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Updated: Jul 30, 2025

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
An electrochemical tandem oxidative azidation and intramolecular cyclization strategy for the synthesis of
Kai Zhou1, Shendan Xia1, Zhiwei Chen1
1College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China. chenzhiwei@zjut.edu.cn.
Abstract:
An electrochemical-oxidation-induced intramolecular annulation for the synthesis of quinoxalines was developed under undivided electrolytic conditions. N-Aryl enamines and TMSN3 as the starting materials could smoothly participate in the transformation to achieve the construction of two C-N bonds through tandem azidation and cyclic amination reactions. The reaction could be easily handled and avoided the use of transition metal catalysts as well as chemical oxidants, which makes it compatible with the sustainable development of green chemistry.
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