Related Experiment Video

Updated: Jul 30, 2025

A Fluorescence-based Assay of Phospholipid Scramblase Activity
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A Fluorescence-based Assay of Phospholipid Scramblase Activity

Published on: September 20, 2016

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Physiological and Pathological Functions of TMEM30A: An Essential Subunit of P4-ATPase Phospholipid Flippases

Jingyi Li1, Yue Zhao2, Na Wang1

  • 1Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.

Journal of Lipids
|May 18, 2023
PubMed

Insights

Transmembrane protein 30A (TMEM30A) is crucial for maintaining cell membrane lipid asymmetry. Its loss triggers apoptosis, highlighting TMEM30A as a potential drug target for various diseases.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Phospholipids exhibit asymmetric distribution in mammalian plasma membranes.
  • P4-ATPases function as lipid flippases, maintaining phosphatidylserine (PS) and phosphatidylethanolamine (PE) in the inner leaflet.
  • Transmembrane protein 30A (TMEM30A) acts as an essential beta subunit for P4-ATPases, aiding their transport and function.

Purpose of the Study:

  • To review the diverse functions of TMEM30A across biological systems.
  • To present current knowledge on the structural and mechanistic aspects of TMEM30A-P4-ATPase complexes.
  • To explore the therapeutic potential of targeting TMEM30A in disease treatment.

Main Methods:

  • Analysis of TMEM30A knockout mouse and cell line models.
  • Investigation of PS exposure-induced apoptosis signaling pathways.
  • Review of existing literature on TMEM30A structure, function, and disease relevance.

Main Results:

  • Loss of TMEM30A significantly impacts cell and mouse survival.
  • PS exposure due to TMEM30A deficiency triggers apoptosis.
  • TMEM30A plays critical roles in various physiological systems and disease states.

Conclusions:

  • TMEM30A is vital for cellular integrity and survival by regulating lipid asymmetry.
  • Dysfunction of TMEM30A leads to apoptosis, suggesting its involvement in disease pathogenesis.
  • TMEM30A represents a promising therapeutic target for drug discovery in multiple diseases.

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