Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

285
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
285
Drug Therapy01:28

Drug Therapy

75
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
75
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

172
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
172
Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

195
Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
195
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

614
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
614
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

355
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
355

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distress Profiles and Help-Seeking Behaviors Among Diverse Healthcare Workers Participating in a Mental Health Screening Program.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2026
Same author

ClassPass Memberships to Improve Well-Being Among Psychiatry Residents: A Pilot Randomized Controlled Trial.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2026
Same author

Interventions for Bereavement: What Works, What Does Not, and What Might.

JAMA psychiatry·2026
Same author

The role of therapeutic alliance in psilocybin treatment for treatment-resistant depression: A post hoc path analysis.

Journal of affective disorders·2026
Same author

National trends in pharmacist and pharmacy technician suicide: Incidence and associated features.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same author

Job-related problems among 2021 nurse suicides: A thematic analysis.

Nursing management·2025

Related Experiment Video

Updated: Jul 30, 2025

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

111

Pharmacologic Approaches to Suicide Prevention.

Sidney Zisook1, Isabel Domingues1, Jason Compton1

  • 1Department of Psychiatry, University of California, San Diego, San Diego.

Focus (American Psychiatric Publishing)
|May 18, 2023
PubMed
Summary

Medications like ketamine and clozapine show promise for acute and chronic suicidal crises, respectively. Optimizing psychiatric treatment and employing enhanced medication strategies are crucial for suicide prevention.

Keywords:
AntidepressantsDepressionPsychopharmacology/patient outcomeSuicide

More Related Videos

The Forced Swim Test as a Model of Depressive-like Behavior
05:42

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

37.5K
Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
07:58

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

562

Related Experiment Videos

Last Updated: Jul 30, 2025

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

111
The Forced Swim Test as a Model of Depressive-like Behavior
05:42

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

37.5K
Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
07:58

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

562

Area of Science:

  • Psychiatry and Pharmacology
  • Suicidology
  • Mental Health Treatment

Background:

  • Suicide is a significant cause of mortality, often preventable.
  • Effective pharmacological interventions are critical for managing suicidal behavior and preventing suicide.
  • Existing treatments require optimization and novel approaches.

Purpose of the Study:

  • To review the current role of medications in treating suicidal behavior.
  • To discuss the efficacy of various pharmacological agents in suicide prevention.
  • To highlight enhanced medication management strategies for individuals at risk.

Main Methods:

  • Literature review of existing studies on medications for suicidal behavior.
  • Analysis of treatment guidelines and clinical recommendations.
  • Discussion of specific drug classes including ketamine, clozapine, lithium, and antidepressants.

Main Results:

  • Ketamine and esketamine show potential for acute suicidal crises.
  • Clozapine is the sole FDA-approved antisuicidal medication, primarily for schizophrenia/schizoaffective disorder.
  • Lithium is supported for mood disorders; antidepressants can reduce suicidal thoughts/behaviors despite warnings.

Conclusions:

  • Optimizing treatment for underlying psychiatric conditions is paramount.
  • Suicide should be treated as an independent target.
  • Enhanced medication management, including supportive relationships and evidence-based strategies, is recommended.