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Pagetic arthritis. Pathophysiology and management.

A Hadjipavlou, P Lander, H Srolovitz

    Clinical Orthopaedics and Related Research
    |July 1, 1986
    PubMed
    Summary

    Paget's disease treatment focuses on managing pain through bone blood flow modulation. Advanced cases may require surgery like osteotomy or total arthroplasty, with continued therapy to prevent complications.

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    Area of Science:

    • Orthopedics
    • Rheumatology
    • Pathology

    Background:

    • Paget's disease is a chronic bone disorder.
    • It affects bone remodeling, leading to enlarged and weakened bones.
    • Arthritis is a common complication, causing significant pain.

    Purpose of the Study:

    • To review modern concepts in Paget's disease pathogenesis.
    • To outline current treatment strategies for Pagetic arthritis.
    • To correlate disease progression with treatment outcomes.

    Main Methods:

    • Retrospective review of 112 patient records.
    • Analysis of treatment approaches for Paget's disease.
    • Evaluation of outcomes based on disease severity and interventions.

    Main Results:

    • Initial medical treatment modulating bone blood flow effectively manages Pagetic arthritis pain.
    • Persistent pain indicates end-stage cartilage destruction or microfractures.
    • Osteotomy is suitable for deformity without joint space loss.
    • Total arthroplasty addresses advanced cartilage destruction.
    • Post-surgical anti-Pagetic therapy may reduce component loosening.

    Conclusions:

    • Paget's disease management requires a multi-faceted approach.
    • Treatment should be tailored to disease stage and specific complications.
    • Continued anti-Pagetic therapy is crucial, especially after surgical interventions.

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